From I-95 and Philadelphia International Airport:
Take I-95 to I-676 West (Central Philadelphia). Follow I-676 to the Benjamin Franklin Parkway exit. Turn right at the top of the ramp (stop sign) and go to the first traffic light, the Benjamin Franklin Parkway. Turn right onto the Parkwy and travel east one block to 21st Street. Turn right onto 21st Street and travel three blocks.  After passing under train tracks and a roadway, there will be a parking lot on your right and a gray marble building on your left.  The building is One Commerce Square.  Parking is available in an underground parking lot beneath Commerce Square on your left.

From I-76:
Exit I-76 (the Schulkill Expressway) at I-676 (Central Philadelphia). Follow I-676 to the Benjamin Franklin Parkway/23rd Street exit (the first exit after leaving I-76). Follow the exit and stay in the right lane. Go to the second traffic light (21st Street). Turn right onto 21st and go south for three blocks. After passing under train tracks and a roadway, there will be a parking lot on your right and a gray marble building on your left.  The building is One Commerce Square.  Parking is available in an underground parking lot beneath Commerce Square on your left.
 

From New Jersey via the Benjamin Franklin Bridge:
Take the Benjamin Franklin Bridge and follow the signs for I-676 (Central Philadelphia). Take I-676 to the Benjamin Franklin Parkway exit.  Turn right at the top of the ramp at the stop sign and go to the first traffic light, the Benjamin Franklin Parkway.  Turn right onto the Parkway and travel east one block to 21st Street. Turn right onto 21st Street and travel three blocks.  After passing under train tracks and a roadway, there will be a parking lot on your right and a gray marble building on your left.  The building is One Commerce Square.  Parking is available in an underground parking lot beneath Commerce Square on your left.